BDBM223755 6-{[(1r)-1- cyclobutylethyl]amino}- n-ethyl-7-[(trans-4- methylcyclohexyl)methyl]- 8-[(3r)-3- phenylmorpholin-4-yl]- 7h-purine-2-carboxamide::US9540377, 12.17

SMILES CCNC(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(N1CCOC[C@H]1c1ccccc1)n2C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=UTSRINWUWZAGTP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223755   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223755BDBM223755(US9540377, 12.17 | 6-{[(1r)-1- cyclobutylethyl]ami...)
Affinity DataIC50: 1.63nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent