BDBM223764 US9540377, 12.26::n-[(1r)-1- cyclopropylethyl]-8-(3- methylphenyl)-2-(1h- tetrazol-5-yl)-7-[4- (trifluoromethyl)benzyl]- 7h-purin-6-amine

SMILES Cc1cccc(-c2nc3nc(-c4nnn[nH]4)nc(N[C@H](C)C4CC4)c3n2Cc2ccc(C(F)(F)F)cc2)c1

InChI Key InChIKey=ZEANAHQYKPPMMX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223764   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223764BDBM223764(US9540377, 12.26 | n-[(1r)-1- cyclopropylethyl]-8-...)
Affinity DataIC50: 53nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent