BDBM223771 (6-{[(1r)-1- cyclobutylethyl]amino}-8- [(3r)-3-phenylmorpholin-4- yl]-7-[4- (trifluoromethyl)benzyl]- 7h-purin-2-yl)methanol::US9540377, 12.33

SMILES C[C@@H](Nc1nc(CO)nc2nc(N3CCOC[C@H]3c3ccccc3)n(Cc3ccc(cc3)C(F)(F)F)c12)C1CCC1

InChI Key InChIKey=OOVPUEWKLXVJIU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 223771   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 223771BDBM223771(US9540377, 12.33 | (6-{[(1r)-1- cyclobutylethyl]am...)
Affinity DataIC50: 151nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent