BDBM223989 A-395N (6)

SMILES CN(C)[C@@H]1CN(Cc2ccccc2)C[C@H]1c1ccc(cc1)N1CCN(CC1)S(C)(=O)=O

InChI Key InChIKey=VEABDKBNQNHHCB-BJKOFHAPSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 223989   

TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223989(A-395N (6))
Affinity DataKi:  1.83E+3nM ΔG°:  -7.82kcal/molepH: 7.5 T: 2°CAssay Description:For the assay, compounds were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM to ~850 pM using an Echo 550 Acousti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223989(A-395N (6))
Affinity DataIC50:  1.32E+3nMpH: 7.5 T: 2°CAssay Description:For the assay, compounds or nonbiotinylated H3(23-34) peptide were dispensed in assay-ready plates using a three-fold serial dilution from 50 μM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
Abbvie

LigandPNGBDBM223989(A-395N (6))
Affinity DataIC50: >5.00E+4nMT: 2°CAssay Description:IC50 values were determined for compounds A-395 and A-395N at 75 nM of EZH2 trimeric complex (EZH2-EED-SUZ12), 3 μM of human nucleosome and 1 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed