BDBM224043 US9540377, 14.5::n-[(1r)-1- cyclobutylethyl]-2- (ethylsulfonyl)-7- [(trans-4- methylcyclohexyl)meth- yl]-8-[(3r)-3- phenylmorpholin-4-yl]- 7h-purin-6-amine

SMILES CCS(=O)(=O)c1nc(N[C@H](C)C2CCC2)c2c(n1)nc(N1CCOC[C@H]1c1ccccc1)n2C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=YKXMICSOAGVKHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224043   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224043BDBM224043(US9540377, 14.5 | n-[(1r)-1- cyclobutylethyl]-2- (...)
Affinity DataIC50: 20.1nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent