BDBM224081 6-[6-{[(1r)-1- cyclobutylethyl]amino}- 7-[(trans-4- methylcyclohexyl)methyl]- 2-(5-oxo-2,5-dihydro- 1,2,4-oxadiazol-3-yl)- 7h-purin-8-yl]-4-(1- methylethyl)pyridin- 2(1h)-one::US9540377, 15.25

SMILES CC(C)c1cc(-c2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)[nH]c(=O)c1

InChI Key InChIKey=BHXMSZBBRLVTPM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224081   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224081BDBM224081(US9540377, 15.25 | 6-[6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 6.74nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent