BDBM224096 3-{7-[(trans-4- methylcyclohexyl) methyl]-8-[4-(1- methylethyl)pyridin- 2-yl]-6-(3- methylphenyl)-7h- purin-2-yl}-1,2,4- oxadiazol-5(4h)-one::US9540377, 16.15

SMILES Cc1cccc(-c2nc(-c3noc(=O)[nH]3)nc3nc(-c4cc(C(C)C)ccn4)n(C[C@H]4CC[C@H](C)CC4)c23)c1

InChI Key InChIKey=VEFQMMPSVGUIND-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224096   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224096BDBM224096(US9540377, 16.15 | 3-{7-[(trans-4- methylcyclohexy...)
Affinity DataIC50: 30.0nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent