BDBM224132 3-[6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylcyclohexyl) methyl]-8-(octahydro- 4h-1,4-benzoxazin-4- yl)-7h-purin-2-yl]- 1,2,4-oxadiazol- 5(4h)-one (enantiomer 1)::US9540377, 16.51::US9540377, 16.52

SMILES C[C@H]1CC[C@H](Cn2c(N3CCOC4CCCCC43)nc3nc(-c4noc(=O)[nH]4)nc(-c4cncc(Cl)c4)c32)CC1

InChI Key InChIKey=PPNAAEISNSMFCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224132   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224132BDBM224132(US9540377, 16.51 | 3-[6-(5- chloropyridin-3-yl)- 7...)
Affinity DataIC50: 1.00nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224132BDBM224132(US9540377, 16.51 | 3-[6-(5- chloropyridin-3-yl)- 7...)
Affinity DataIC50: 30.1nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent