BDBM224222 3-{6-(5- chloropyridin-3-yl)- 7-[(trans-4- methylcyclohexyl) methyl]-8-[2-(5-methyl- 1,3,4-oxadiazol-2- yl)pyrrolidin-1-yl]- 7h-purin-2-yl}-1,2,4- oxadiazol-5(4h)-one (racemate)::US9540377, 16.141

SMILES Cc1nnc(C2CCCN2c2nc3nc(-c4noc(=O)[nH]4)nc(-c4cncc(Cl)c4)c3n2C[C@H]2CC[C@H](C)CC2)o1

InChI Key InChIKey=GNBNCCUHOCLHMY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224222   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224222BDBM224222(US9540377, 16.141 | 3-{6-(5- chloropyridin-3-yl)- ...)
Affinity DataIC50: 26.8nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent