BDBM224235 5-{6-(5- chloropyridin-3-yl)- 8-[(cis)-4-methoxy-2- methylpiperidin-1- yl]-7-[(trans-4- methylcyclohexyl) methyl]-7h-purin-2-yl}- 1,3,4-oxadiazol- 2(3h)-one (racemate)::US9540377, 16.154::US9540377, 16.155

SMILES COC1CCN(c2nc3nc(-c4n[nH]c(=O)o4)nc(-c4cncc(Cl)c4)c3n2C[C@H]2CC[C@H](C)CC2)C(C)C1

InChI Key InChIKey=JRMSAGQVAUUCJU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224235   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224235BDBM224235(US9540377, 16.154 | 5-{6-(5- chloropyridin-3-yl)- ...)
Affinity DataIC50: 49.1nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224235BDBM224235(US9540377, 16.154 | 5-{6-(5- chloropyridin-3-yl)- ...)
Affinity DataIC50: 67.2nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent