BDBM224249 5-{7-[(trans-4- methylcyclohexyl) methyl]-8-[(3r)-3- phenylmorpholin-4- yl]-6-(tetrahydro-2h- pyran-4-yl)-7h- purin-2-yl}-1,3,4- oxadiazol-2(3h)-one::US9540377, 16.168

SMILES C[C@H]1CC[C@H](Cn2c(N3CCOC[C@H]3c3ccccc3)nc3nc(-c4n[nH]c(=O)o4)nc(C4CCOCC4)c32)CC1

InChI Key InChIKey=YJRQJWMEXPIUBK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224249   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224249BDBM224249(US9540377, 16.168 | 5-{7-[(trans-4- methylcyclohex...)
Affinity DataIC50: 67.1nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent