BDBM224276 6-(((r)-1-cyclobutylethyl)amino)-7- ((trans-4-ethylcyclohexyl)methyl)-8- (4-isopropylpyridin-2-yl)-7h-purine- 2-carboxylic acid::US9540377, 18.17::US9540377, 18.2

SMILES CC[C@H]1CC[C@H](Cn2c(-c3cc(C(C)C)ccn3)nc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1

InChI Key InChIKey=WLLLONIWVLNEEB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224276   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224276BDBM224276(US9540377, 18.2 | US9540377, 18.17 | 6-(((r)-1-cyc...)
Affinity DataIC50: 2.49nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224276BDBM224276(US9540377, 18.2 | US9540377, 18.17 | 6-(((r)-1-cyc...)
Affinity DataIC50: 8.16nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent