BDBM224290 6-{[(1r)-1-cyclobutylethyl]amino}- 7-[(trans-4-ethylcyclohexyl)methyl]- 8-(2-methoxy-5-methylphenyl)-7h- purine-2-carboxylic acid::US9540377, 18.16

SMILES CC[C@H]1CC[C@H](Cn2c(-c3cc(C)ccc3OC)nc3nc(C(=O)O)nc(N[C@H](C)C4CCC4)c32)CC1

InChI Key InChIKey=JMPPFSJHAAWWFK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224290   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224290BDBM224290(US9540377, 18.16 | 6-{[(1r)-1-cyclobutylethyl]amin...)
Affinity DataIC50: 31.8nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent