BDBM224646 3-{6-(3-chlorophenyl)-8-[(3r)-3- ethylmorpholin-4-yl]-7-[1-(trans-4- methylcyclohexyl)ethyl]-7h-purin-2- yl}-1,2,4-oxadiazol-5(4h)-one (diastereomer 1)::US9540377, 18.50::US9540377, 18.51

SMILES CC[C@@H]1COCCN1c1nc2nc(-c3noc(=O)[nH]3)nc(-c3cccc(Cl)c3)c2n1C(C)[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=FZLZTJMCRBEESJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224646   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224646BDBM224646(US9540377, 18.50 | US9540377, 18.51 | 3-{6-(3-chlo...)
Affinity DataIC50: 7.04nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224646BDBM224646(US9540377, 18.50 | US9540377, 18.51 | 3-{6-(3-chlo...)
Affinity DataIC50: 10.5nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent