BDBM224714 3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- (2-fluorophenyl)-1- hydroxyethyl]-7-[(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl)-1,2,4- oxadiazol-5(4h)-one (diastereoisomer a)::US9540377, 22.3::US9540377, 22.4

SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(C(C)(O)c3ccccc3F)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=KVCOYKIMYSHIAZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224714   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224714BDBM224714(US9540377, 22.3 | 3-(6-{[(1r)-1- cyclobutylethyl]a...)
Affinity DataIC50: 7.21nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224714BDBM224714(US9540377, 22.3 | 3-(6-{[(1r)-1- cyclobutylethyl]a...)
Affinity DataIC50: 41.2nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent