BDBM224744 3-(6-{[(1r)-1- cyclobutylethyl]amino}-8- (2,2-dimethyl-1- methylidenepropyl)-7-[(trans- 4-methylcyclohexyl)methyl]- 7h-purin-2-yl)-4-methyl- 1,2,4-oxadiazol-5(4h)-one::US9540377, 22.33

SMILES C=C(c1nc2nc(-c3noc(=O)n3C)nc(N[C@H](C)C3CCC3)c2n1C[C@H]1CC[C@H](C)CC1)C(C)(C)C

InChI Key InChIKey=JUDCHQSCGOAEOT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 224744   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224744BDBM224744(US9540377, 22.33 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 291nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent