BDBM224761 3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- hydroxy-1-(1,3-thiazol-4- yl)ethyl]-7-[(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl)-1,2,4- oxadiazol-5(4h)-one::US9540377, 22.50::US9540377, 22.52

SMILES C[C@@H](Nc1nc(-c2noc(=O)[nH]2)nc2nc(C(C)(O)c3cscn3)n(C[C@H]3CC[C@H](C)CC3)c12)C1CCC1

InChI Key InChIKey=PNEHWVATSWGZCX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 224761   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224761BDBM224761(US9540377, 22.50 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 1.85nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 224761BDBM224761(US9540377, 22.50 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 10.3nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent