BDBM225085 US9321756, 54

SMILES CC(C)(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1

InChI Key InChIKey=BQKBRLMFCCUJQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 225085   

TargetSerine/threonine-protein kinase pim-2(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 225085BDBM225085(US9321756, 54)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to PIM2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 225085BDBM225085(US9321756, 54)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to PIM1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 225085BDBM225085(US9321756, 54)
Affinity DataIC50: 1.58nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 225085BDBM225085(US9321756, 54)
Affinity DataIC50: 2.40nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
US Patent