BDBM225903 3-(6-{[(1r)-1- cyclobutylethyl]amino}-8-[1- (2,5-dimethyl-1,3-thiazol-4- yl)-1-fluoroethyl]-7-[(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl)-1,2,4- oxadiazol-5(4h)-one (diastereomer 1)::US9540377, 22.73::US9540377, 22.75

SMILES Cc1nc(C(C)(F)c2nc3nc(-c4noc(=O)[nH]4)nc(N[C@H](C)C4CCC4)c3n2C[C@H]2CC[C@H](C)CC2)c(C)s1

InChI Key InChIKey=IDLCDIGLTRBYIP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 225903   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 225903BDBM225903(US9540377, 22.73 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 4.06nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 225903BDBM225903(US9540377, 22.73 | 3-(6-{[(1r)-1- cyclobutylethyl]...)
Affinity DataIC50: 5.48nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent