BDBM227469 3-{6-(3-chlorophenyl)-8- [1-methoxy-1-(5-methyl- 1,3-oxazol-4-yl)ethyl]-7- [(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl}-1,2,4- oxadiazol-5(4h)-one (racemate)::US9540377, 23.57

SMILES COC(C)(c1ncoc1C)c1nc2nc(-c3noc(=O)[nH]3)nc(-c3cccc(Cl)c3)c2n1C[C@H]1CC[C@H](C)CC1

InChI Key InChIKey=IDQWGBZTRFPRJP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227469   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 227469BDBM227469(US9540377, 23.57 | 3-{6-(3-chlorophenyl)-8- [1-met...)
Affinity DataIC50: 2.07nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent