BDBM227705 5-chloro-1-{7-[(trans-4- methylcyclohexyl)methyl]- 2-(5-oxo-4,5-dihydro- 1,2,4-oxadiazol-3-yl)-8- [(3r)-3-phenylmorpholin- 4-yl]-7h-purin-6- yl}pyridin-2(1h)-one::US9540377, 25.1

SMILES C[C@H]1CC[C@H](Cn2c(N3CCOC[C@H]3c3ccccc3)nc3nc(-c4noc(=O)[nH]4)nc(-n4cc(Cl)ccc4=O)c32)CC1

InChI Key InChIKey=FDQYFSVYQCKXBW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 227705   

TargetE3 ubiquitin-protein ligase Mdm2 [17-125](Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 227705BDBM227705(US9540377, 25.1 | 5-chloro-1-{7-[(trans-4- methylc...)
Affinity DataIC50: 1.01nMT: 2°CAssay Description:An HDM2 FRET assay was developed to assess the compounds' inhibitory activity towards binding of p53 protein. A truncated version of HDM2 with re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent