BDBM227712 US9556157, 3::n-((5-amino-2,6-dimethyl-4-oxo-1,4-dihydropyridin-3-yl)methyl)-5-(((trans)-4-(dimethylamino)cyclohexyl)(ethyl)amino)-4-methylthiophene-3-carboxamide

SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1scc(C(=O)NCc2c(C)[nH]c(C)c(N)c2=O)c1C

InChI Key InChIKey=RGHDJONNJIYGHV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227712   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50: 16nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Glaxosmithkline

US Patent
LigandPNGBDBM227712(US9556157, 3 | n-((5-amino-2,6-dimethyl-4-oxo-1,4-...)
Affinity DataIC50: 32nMpH: 8.0 T: 2°CAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2018
Entry Details
US Patent