BDBM227765 8-[(Diethylamino)methyl]-4-[(2-fluoro-5-hydroxy-4-methylphenyl)amino]-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one::US10047096, 193::US10047096, 28

SMILES CCN(CC)Cc1ccc2Nc3nccc(Nc4cc(O)c(C)cc4F)c3C(=O)Nc2c1

InChI Key InChIKey=GMNBLWOJWJDQBB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 227765   

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227765(US10047096, 28 | US10047096, 193 | 8-[(Diethylamin...)
Affinity DataIC50: 0.401nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227765(US10047096, 28 | US10047096, 193 | 8-[(Diethylamin...)
Affinity DataIC50: 0.953nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFR (amino acids R561-L1106), expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227765(US10047096, 28 | US10047096, 193 | 8-[(Diethylamin...)
Affinity DataIC50: 1.72nMpH: 7.0Assay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM227765(US10047096, 28 | US10047096, 193 | 8-[(Diethylamin...)
Affinity DataIC50: 3.22nMpH: 7.5 T: 2°CAssay Description:The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human PDGFR (amino acids R561-L1106), expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2018
Entry Details
US Patent