BDBM22813 5-chloro-2,3-dihydro-1H-indole-2,3-dione::Isatin-based compound, 33

SMILES c1cc2c(cc1Cl)C(=O)C(=O)N2

InChI Key InChIKey=XHDJYQWGFIBCEP-UHFFFAOYSA-N

Data  5 KI  2 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 22813   

TargetLiver carboxylesterase 1(Human)
St. Jude Research Hospital

LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  1.22E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetLiver carboxylesterase 1(Rabbit)
St. Jude Research Hospital

LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  4.37E+3nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
St. Jude Research Hospital

LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi:  1.49E+4nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetProtein-glutamine gamma-glutamyltransferase 2(Human)
Stanford University

Curated by ChEMBL
LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of human transglutaminase 2 using Cbz-Gln-Gly as a substrate by GDH-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCholinesterase(Human)
St. Jude Research Hospital

LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2008
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM22813(5-chloro-2,3-dihydro-1H-indole-2,3-dione | Isatin-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin) using histone H1 as substrate by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed