BDBM228449 BDBM229609::US9340506, G3B::US9556135, 71
SMILES CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3nc(O)cnc23)cc(F)c1F
InChI Key InChIKey=GVPKIUOCZPFRMD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 228449
Affinity DataIC50: 3.70nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Affinity DataEC50: 420nMpH: 7.2Assay Description:The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.12E+3nMpH: 7.2Assay Description:The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.52E+4nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair