BDBM228460 BDBM229620::US9340506, G1B::US9556135, 147

SMILES C[C@]1(CS(=O)(=O)C2(CCC2)C(N)=N1)c1cc(Br)ncc1F

InChI Key InChIKey=OJSKGLKVCSCGHR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 228460   

TargetHexokinase-4(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM228460(US9556135, 147 | BDBM229620 | US9340506, G1B)
Affinity DataEC50:  87nMpH: 7.2Assay Description:The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetHexokinase-4(Human)
Advinus Therapeutics

US Patent
LigandPNGBDBM228460(US9556135, 147 | BDBM229620 | US9340506, G1B)
Affinity DataEC50:  330nMpH: 7.2Assay Description:The assay is carried out according to the protocol outlined in Hariharan et al (1997), Diabetes 46: 11-16. Briefly, the test compounds are incubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2017
Entry Details
US Patent

TargetBeta-secretase 1(Human)
Amgen

US Patent
LigandPNGBDBM228460(US9556135, 147 | BDBM229620 | US9340506, G1B)
Affinity DataIC50: 1.70E+4nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetCathepsin D(Human)
Amgen

US Patent
LigandPNGBDBM228460(US9556135, 147 | BDBM229620 | US9340506, G1B)
Affinity DataIC50: 4.35E+4nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent