BDBM233024 2-(3-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)-2-hydroxypropyl)isoindoline-1,3-dione hydrochloride (A2-04)

SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCC(O)CN2C(=O)c3ccccc3C2=O)cc1

InChI Key InChIKey=VDICEBRZUJPQQK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 233024   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute of Chemical Technology

LigandPNGBDBM233024(2-(3-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(...)
Affinity DataIC50: 523nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Institute of Chemical Technology

LigandPNGBDBM233024(2-(3-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(...)
Affinity DataIC50: 1.94E+3nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute of Chemical Technology

LigandPNGBDBM233024(2-(3-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(...)
Affinity DataIC50: 3.46E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Institute of Chemical Technology

LigandPNGBDBM233024(2-(3-(4-(4,6-Diamino-2,2-dimethyl-1,3,5-triazin-1(...)
Affinity DataIC50: 1.54E+5nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed