BDBM233034 1-(4-(2,4-Dichlorobenzyloxy)phenyl)-6,6-dimethyl-1-,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride (B2-04)

SMILES CC1(C)N=C(N)N=C(N)N1c1ccc(OCc2ccc(Cl)cc2Cl)cc1

InChI Key InChIKey=GFTNXWXBGUTRIZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 233034   

TargetDihydrofolate reductase(Rat)
Institute of Chemical Technology

LigandPNGBDBM233034(1-(4-(2,4-Dichlorobenzyloxy)phenyl)-6,6-dimethyl-1...)
Affinity DataIC50: 18nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Institute of Chemical Technology

LigandPNGBDBM233034(1-(4-(2,4-Dichlorobenzyloxy)phenyl)-6,6-dimethyl-1...)
Affinity DataIC50: 29nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Institute of Chemical Technology

LigandPNGBDBM233034(1-(4-(2,4-Dichlorobenzyloxy)phenyl)-6,6-dimethyl-1...)
Affinity DataIC50: 1.08E+3nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Institute of Chemical Technology

LigandPNGBDBM233034(1-(4-(2,4-Dichlorobenzyloxy)phenyl)-6,6-dimethyl-1...)
Affinity DataIC50: 1.12E+4nMAssay Description:The synthesized compounds were evaluated for their ability to inhibit DHFR from pc, tg, ma, and rl using a continuous spectrophotometric assay measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/15/2017
Entry Details Article
PubMed