BDBM234863 US9353116, Fig. 16, Compound 2

SMILES COc1cc2ncnc(Nc3cccc(NS(C)(=O)=O)c3)c2cc1OC

InChI Key InChIKey=VOQXQKBOJZIREZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 234863   

TargetLeucine-rich repeat serine/threonine-protein kinase 2 [G2019S](Human)
University of California

US Patent
LigandPNGBDBM234863(US9353116, Fig. 16, Compound 2)
Affinity DataIC50: 100nMAssay Description:In vitro kinase assays using LRRK WT and LRRK G2019S.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
University of California

US Patent
LigandPNGBDBM234863(US9353116, Fig. 16, Compound 2)
Affinity DataIC50: 353nMAssay Description:In vitro kinase assays using LRRK WT and LRRK G2019S.More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2017
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM234863(US9353116, Fig. 16, Compound 2)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of N-terminal GST fused human RET (658 to 1114 amino acid residue) using CSKtide as substrate expressed in baculovirus preincubated for 15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed
LigandPNGBDBM234863(US9353116, Fig. 16, Compound 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KIF5B/RET (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by Ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM234863(US9353116, Fig. 16, Compound 2)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant KDR (unknown origin) expressed in IL3 deficient BAF3 cells assessed as reduction in cell viability after 48 hrs by CellTite...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2017
Entry Details Article
PubMed