BDBM234959 US9556148, 27::n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]dioxino[2,3-c]pyrrol-6(3h)-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)benzamide

SMILES O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCC(CC2)N2CC3OCCOC3C2)n1

InChI Key InChIKey=GFUZZGUULWEEMA-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 234959   

TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 5nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human JAK2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 10nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 10nMAssay Description:Inhibition of human JAK1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 49nMT: 2°CAssay Description:NCEs were screened using in vitro JAK (1, 2 and 3) kinase assay on ADP Glo platform (Promega). Fixed amount of recombinant purified human JAK (25 ng ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2018
Entry Details
US Patent

TargetTyrosine-protein kinase JAK3(Human)
Cadila Healthcare

US Patent
LigandPNGBDBM234959(n-(cyanomethyl)-4-(2-((4-(4-(tetrahydro-2h-[1,4]di...)
Affinity DataIC50: 49nMAssay Description:Inhibition of human JAK3 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed