BDBM23501 BMCL193445 Compound 2d::beta-sulfonyl hydroxamate analogue, 5::tert-butyl 4-({[4-(but-2-yn-1-yloxy)benzene]sulfonyl}methyl)-4-(hydroxycarbamoyl)piperidine-1-carboxylate

SMILES CC#CCOc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)C(=O)OC(C)(C)C)C(=O)NO

InChI Key InChIKey=XOBSNYRLSVUYKY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 23501   

LigandPNGBDBM23501(tert-butyl 4-({[4-(but-2-yn-1-yloxy)benzene]sulfon...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
LigandPNGBDBM23501(tert-butyl 4-({[4-(but-2-yn-1-yloxy)benzene]sulfon...)
Affinity DataIC50: 2nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23501(tert-butyl 4-({[4-(but-2-yn-1-yloxy)benzene]sulfon...)
Affinity DataIC50: 135nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23501(tert-butyl 4-({[4-(but-2-yn-1-yloxy)benzene]sulfon...)
Affinity DataIC50: 135nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2009
Entry Details Article
PubMed