BDBM23504 beta-sulfonyl hydroxamate analogue, 12::tert-butyl 4-[({4-[(4-hydroxybut-2-yn-1-yl)amino]benzene}sulfonyl)methyl]-4-(hydroxycarbamoyl)piperidine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCC(CS(=O)(=O)c2ccc(NCC#CCO)cc2)(CC1)C(=O)NO

InChI Key InChIKey=HPBWNXRDTAWPAP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23504   

LigandPNGBDBM23504(tert-butyl 4-[({4-[(4-hydroxybut-2-yn-1-yl)amino]b...)
Affinity DataIC50: 10nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23504(tert-butyl 4-[({4-[(4-hydroxybut-2-yn-1-yl)amino]b...)
Affinity DataIC50: 334nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23504(tert-butyl 4-[({4-[(4-hydroxybut-2-yn-1-yl)amino]b...)
Affinity DataIC50: 1.04E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed