BDBM23507 4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(pyridin-4-ylmethyl)piperidine-4-carboxamide::beta-sulfonyl hydroxamate analogue, 18

SMILES CC#CCNc1ccc(cc1)S(=O)(=O)CC1(CCN(Cc2ccncc2)CC1)C(=O)NO

InChI Key InChIKey=CLSBMSGIRGYRMI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 23507   

LigandPNGBDBM23507(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 6.40nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23507(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 1.53E+3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

LigandPNGBDBM23507(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 4.32E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23507(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 6.88E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed