BDBM23510 4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl)-N-hydroxy-1-(2-methylbutanoyl)piperidine-4-carboxamide::beta-sulfonyl hydroxamate analogue, 21

SMILES CCC(C)C(=O)N1CCC(CS(=O)(=O)c2ccc(NCC#CC)cc2)(CC1)C(=O)NO

InChI Key InChIKey=CBEZXYHTYKUDTE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 23510   

LigandPNGBDBM23510(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 3.5nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23510(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 1.31E+3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23510(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 2.48E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

LigandPNGBDBM23510(4-({[4-(but-2-yn-1-ylamino)benzene]sulfonyl}methyl...)
Affinity DataIC50: 7.05E+3nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed