BDBM23512 (3S)-4-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide::beta-sulfonyl hydroxamate analogue, 26

SMILES CC#CCNc1ccc(cc1)S(=O)(=O)N1CCSC(C)(C)[C@@H]1C(=O)NO

InChI Key InChIKey=YLRFPZVTHHHQAF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23512   

LigandPNGBDBM23512((3S)-4-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}-N...)
Affinity DataIC50: 2.30nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23512((3S)-4-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}-N...)
Affinity DataIC50: 30nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23512((3S)-4-{[4-(but-2-yn-1-ylamino)benzene]sulfonyl}-N...)
Affinity DataIC50: 56nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed