BDBM23514 N-hydroxy-4-[({4-[(2-methylpent-3-yn-2-yl)oxy]benzene}sulfonyl)methyl]-1-(propane-2-sulfonyl)piperidine-4-carboxamide::beta-sulfonyl hydroxamate analogue, 28

SMILES CC#CC(C)(C)Oc1ccc(cc1)S(=O)(=O)CC1(CCN(CC1)S(=O)(=O)C(C)C)C(=O)NO

InChI Key InChIKey=SVFGAFGHEBEAJE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 23514   

LigandPNGBDBM23514(N-hydroxy-4-[({4-[(2-methylpent-3-yn-2-yl)oxy]benz...)
Affinity DataIC50: 27nMpH: 7.4 T: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

LigandPNGBDBM23514(N-hydroxy-4-[({4-[(2-methylpent-3-yn-2-yl)oxy]benz...)
Affinity DataIC50: 1.67E+3nMpH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

LigandPNGBDBM23514(N-hydroxy-4-[({4-[(2-methylpent-3-yn-2-yl)oxy]benz...)
Affinity DataIC50: 1.20E+4nMT: 2°CAssay Description:Compounds were tested for their ability to inhibit the cleavage of the substrate by the purified enzyme in a fluorescence-based fluorescence resonanc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2008
Entry Details Article
PubMed