BDBM235634 (E)-1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)-2-propen-1-one (4)

SMILES COc1ccccc1/C=C/C(=O)c2ccc(cc2O)O

InChI Key InChIKey=ODLVGCCGMXGMGZ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 235634   

TargetBeta-secretase 1(Human)
Shanghai Institute of Material Medica, Chinese Academy of Sciences

LigandPNGBDBM235634((E)-1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)-2-...)
Affinity DataIC50: 2.63E+3nMpH: 4.5 T: 2°CAssay Description:The assay based on fluorescenceresonance energy transfer was carried out with BACE1 enzyme at pH 4.5 with a substrate, H-Lys(DABSYL)-SEVNLDAEFR-Gin-(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2017
Entry Details Article
PubMed
TargetBile acid receptor(Human)
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM235634((E)-1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)-2-...)
Affinity DataIC50: 4.29E+3nMAssay Description:Antagonist activity at GAL4-DBD fused human FXR LBD expressed in HEK293T cells assessed as inhibition of CDCA-induced receptor activation after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2019
Entry Details Article
PubMed