BDBM236632 US9388136, Table 1, Compound 24:tert-butyl N-(2- {4-[6-amino-5- (2,4-difluoro- benzoyl)-2- oxopyridin- 1(2H)-yl]-3,5- difluorophenyl} ethyl)-O-tert- butyl-L-serinate

SMILES CC(C)(C)OC[C@H](NCCc1cc(F)c(c(F)c1)-n1c(N)c(ccc1=O)C(=O)c1ccc(F)cc1F)C(=O)OC(C)(C)C

InChI Key InChIKey=WRGVAZIJXDACKY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 236632   

TargetMitogen-activated protein kinase 14(Human)
Chroma Therapeutics

US Patent
LigandPNGBDBM236632(US9388136, Table 1, Compound 24:tert-butyl N-(2- {...)
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetMitogen-activated protein kinase 14(Human)
Chroma Therapeutics

US Patent
LigandPNGBDBM236632(US9388136, Table 1, Compound 24:tert-butyl N-(2- {...)
Affinity DataIC50: 72nMpH: 7.5 T: 2°CAssay Description:The ability of compounds to inhibit p38 MAP a Kinase activity was measured in an assay performed by Upstate (Dundee UK). In a final reaction volume o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent