BDBM236667 US9388140, 8

SMILES CC(C)CNc1cc(cc2n(cnc12)-c1ccc(cc1)C(=O)NC1CC1)-c1ccccc1

InChI Key InChIKey=WFQNVXVCPSPGPD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 236667   

TargetDual specificity protein kinase TTK(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM236667(US9388140, 8)
Affinity DataIC50: 5nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM236667(US9388140, 8)
Affinity DataIC50: 5.30nMpH: 7.7 T: 2°CAssay Description:For the assay 50 nL of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetDual specificity protein kinase TTK(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM236667(US9388140, 8)
Affinity DataIC50: 292nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM236667(US9388140, 8)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed