BDBM236877 US9388171, I-5

SMILES OC[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)cc2n1)c1ccc(Cl)c(F)c1

InChI Key InChIKey=SDLDUDKFDXGWAV-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 236877   

TargetMitogen-activated protein kinase 1(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM236877(US9388171, I-5)
Affinity DataKi:  0.360nMAssay Description:Binding affinity to ERK2 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 1 [8-360](Human)
Genetech

US Patent
LigandPNGBDBM236877(US9388171, I-5)
Affinity DataIC50: 4.04nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

LigandPNGBDBM236877(US9388171, I-5)
Affinity DataKi:  11nMAssay Description:Binding affinity to CDK2/Cyclin E1 (unknown origin) using Ulight-MBP as substrate assessed as inhibition constant preincubated for 30 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Genetech

US Patent
LigandPNGBDBM236877(US9388171, I-5)
Affinity DataIC50: 16.3nMT: 2°CAssay Description:HepG2 cells were obtained from ATCC and grown in DMEM supplemented with 10% fetal bovine serum. Cells were plated in 96-well plates at 35,000 cells/w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent