BDBM238900 US9403827, 2
SMILES COc1ccccc1-c1nc2NC(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1C)c1cccc(Cl)c1F
InChI Key InChIKey=BRXMLZRLZJJZCH-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 238900
TargetCellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188](Human)
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 2.10nMT: 25°CAssay Description:Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188](Human)
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 779nMT: 25°CAssay Description:Assay 2: For selected compounds displaying IC50s between 0.05 and 5 nM on MDM2, a slightly modified assay is used with the following adaptations: 0.1...More data for this Ligand-Target Pair
Affinity DataIC50: 2.13E+3nMT: 25°CAssay Description:Assay 1: This assay was used to evaluate compounds displaying inhibition of p53-MDM2 interaction and p53-MDM4 interaction at IC50s of 0.005 to 50 &mu...More data for this Ligand-Target Pair