BDBM239621 US9394309, 147::US9394309, 74

SMILES Cc1cc(C)c(cc1NC(=O)c1cc(cc(c1)S(F)(F)(F)(F)F)C#N)-n1ccn2nc(cc12)-c1cccnc1

InChI Key InChIKey=MPASHPJAIUOWCK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 239621   

TargetAngiopoietin-1 receptor [776-1124](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataIC50: 0.200nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetEpithelial discoidin domain-containing receptor 1(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataKd:  0.400nMAssay Description:Binding affinity to DDR1 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiopoietin-1 receptor [776-1124](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataIC50: 0.5nMpH: 7.0 T: 2°CAssay Description:For the assay, 50 nl of a 100-fold concentrated solution of the respective test substance in DMSO were pipetted into a black low-volume 384-well micr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetAngiopoietin-1 receptor [776-1124](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataIC50: 0.600nMpH: 9.6 T: 2°CAssay Description:For measuring the autophosphorylation of the endogenous Tie2 receptor in the cell lysates prepared, a self-prepared anti-Tie2 antibody directed again...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetTyrosine-protein kinase receptor Tie-1(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataKd:  0.900nMAssay Description:Binding affinity to TIE1 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataKd:  1.30nMAssay Description:Binding affinity to DDR2 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of TIE2 autophosphorylation in human HUVEC cells by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataKd:  1.60nMAssay Description:Binding affinity to TIE2 (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 10(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataKd:  5.90nMAssay Description:Binding affinity to LOK (unknown origin) assessed as dissociation constant by KINOME scan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAngiopoietin-1 receptor(Human)
University Hospital and University of Zurich

Curated by ChEMBL
LigandPNGBDBM239621(US9394309, 147 | US9394309, 74)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed