BDBM239901 US9403767, 64::US9403767, 65

SMILES CN(C)C1(CC2CCCC2)CCC(CC1)(N(C)C(=O)\C=C\c1ccccc1)c1ccccc1

InChI Key InChIKey=FPGBNGHIRYAIFR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 239901   

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM239901(US9403767, 65 | US9403767, 64)
Affinity DataKi:  5.30nM ΔG°:  -11.3kcal/moleT: 2°CAssay Description:The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM239901(US9403767, 65 | US9403767, 64)
Affinity DataKi:  34.5nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM239901(US9403767, 65 | US9403767, 64)
Affinity DataKi:  92.5nM ΔG°:  -9.59kcal/moleT: 2°CAssay Description:The affinity to the human μ-opiate receptor was determined in a homogeneous preparation in microtiter plates. For this, dilution series of the res...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM239901(US9403767, 65 | US9403767, 64)
Affinity DataKi:  435nMpH: 7.4Assay Description:The compounds were examined with membranes of recombinant CHO-ORL 1 cells in a receptor binding assay with 3H-nociceptin/orphanin FQ. This test syste...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2017
Entry Details
US Patent