BDBM241947 US9428466, 4'-hydroxymerbarone

SMILES Oc1ccc(NC(=O)c2c(O)[nH]c(=S)[nH]c2=O)cc1

InChI Key InChIKey=DVMISDHNZIDREG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 241947   

TargetXanthine dehydrogenase/oxidase(Human)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 680nMAssay Description:Inhibition of XO (unknown origin) by fluorescence based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetXanthine dehydrogenase/oxidase(Human)
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 680nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 9.40E+3nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/7/2017
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
TBA

US Patent
LigandPNGBDBM241947(US9428466, 4'-hydroxymerbarone)
Affinity DataIC50: 9.40E+3nMAssay Description:Displacement of 3H-orotate from URAT1 (unknown origin) stably transfected in CHO cells assessed as reduction in uric acid level by liquid scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed