BDBM242959 US9422277, 22::US9422277, 84
SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1sc(cc1Cl)-c1nnc(o1)-c1ccc(F)cc1
InChI Key InChIKey=GHVBKTVASKIYHA-KRWDZBQOSA-N
Data 4 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 242959
Affinity DataKi: 10.6nM ΔG°: -11.1kcal/molepH: 5.0 T: 30°CAssay Description:Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0....More data for this Ligand-Target Pair
Affinity DataKi: 13.0nM ΔG°: -10.9kcal/molepH: 5.0 T: 30°CAssay Description:Inhibitor compounds, prepared at 3× the desired final concentration in 1×BACE assay buffer (20 mM sodium acetate pH 5.0, 10% glycerol, 0....More data for this Ligand-Target Pair
Affinity DataKi: 65.5nM ΔG°: -9.96kcal/molepH: 5.0 T: 30°CAssay Description:Varying concentrations of inhibitors at 3× the final desired concentration in a volume of 10 ul are preincubated with purified human BACE1 cata...More data for this Ligand-Target Pair
Affinity DataKi: 102nM ΔG°: -9.69kcal/molepH: 5.0 T: 30°CAssay Description:Varying concentrations of inhibitors at 3× the final desired concentration in a volume of 10 ul are preincubated with purified human BACE1 cata...More data for this Ligand-Target Pair