BDBM24476 7-methoxy-4-{[6-(3,4,5-trifluorophenyl)-[1,2,4]triazolo[4,3-a]pyridazin-3-yl]methoxy}quinoline::Triazolopyridazine, 10f
SMILES COc1ccc2c(OCc3nnc4ccc(nn34)-c3cc(F)c(F)c(F)c3)ccnc2c1
InChI Key InChIKey=MLHUEVZLHPFKKC-UHFFFAOYSA-N
Data 9 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 24476
Affinity DataIC50: 4nMpH: 7.4 T: 22°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. Mole...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant MET (unknown origin) using gastrin peptide as substrate preincubated for 30 mins followed by substrate addition incubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of HGF-mediated MET autophosphorylation in human PC3 cells preincubated for 1 hr followed by stimulation with human HGF measured after 10 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) in presence of NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human CYP3A4 in human liver microsomes preincubated with NADPHMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) in absence of NADPHMore data for this Ligand-Target Pair