BDBM246033 US9433622, DMX- 38

SMILES OC[C@@H](O)Cn1cc(Nc2nccc(n2)-c2cnc(N3CCCC3)c(c2)C#N)cn1

InChI Key InChIKey=AEGHJSIDRASQIE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246033   

TargetSerine/threonine-protein kinase TBK1(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246033(US9433622, DMX- 38)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246033(US9433622, DMX- 38)
Affinity DataIC50: 100nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent