BDBM246043 US9433622, DMX- 48

SMILES OCCNC(=O)c1ccc(Nc2nccc(n2)-c2cnc(N3CC[C@H](F)C3)c(c2)C#N)cc1

InChI Key InChIKey=IYUAMICJCNEZTC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246043   

TargetSerine/threonine-protein kinase TBK1(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246043(US9433622, DMX- 48)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246043(US9433622, DMX- 48)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent