BDBM246083 US9433622, DMX- 149

SMILES C[C@H]1COCCN1Cc1ccc(Nc2nccc(n2)-c2cc(C#N)c(N3CC[C@H](F)C3)c(n2)C#N)cn1

InChI Key InChIKey=VCDBIBIVKYVZFS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 246083   

TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246083(US9433622, DMX- 149)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Case Western Reserve University

US Patent
LigandPNGBDBM246083(US9433622, DMX- 149)
Affinity DataIC50: 15nMpH: 7.5Assay Description:Kinase inhibition assays (10 μL) were performed at 20° C. in 384-well plate format. Compound IC50 values were determined at the apparent Km for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent