BDBM248964 US9434725, 195::US9434725, 203::US9434725, 204

SMILES CC1C(N)CCCN1c1cccc(n1)-n1ncc2cnc(cc12)-c1cncc(C)n1

InChI Key InChIKey=AVOZYOVWQGVLHZ-UHFFFAOYSA-N

Data  9 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 248964   

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.0250nM ΔG°:  -14.5kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.0340nM ΔG°:  -14.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.0570nM ΔG°:  -14.0kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.0650nM ΔG°:  -13.9kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.331nM ΔG°:  -12.9kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.375nM ΔG°:  -12.9kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  0.477nM ΔG°:  -12.7kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  1.03nM ΔG°:  -12.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataKi:  4.83nM ΔG°:  -11.3kcal/molepH: 7.2 T: 2°CAssay Description:PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Mouse)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataIC50: 693nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Mouse)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataIC50: 1.00E+3nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Mouse)
F. Hoffmann-La Roche

US Patent
LigandPNGBDBM248964(US9434725, 195 | US9434725, 203 | US9434725, 204)
Affinity DataIC50: 2.00E+3nMAssay Description:BaF3, a murine interleukin-3 dependent pro-B cell line, parental cells, BaF3 PIM1 cells, BaF3 PIM2 cells, and MM1.S (multiple myeloma) cells were see...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details
US Patent